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ADAPTABLE, the Aspirin Study – A Patient-Centered Trial

ADAPTABLE (Aspirin Dosing: A Patient-centric Trial Assessing Benefits and Long-Term Effectiveness)  will compare the effectiveness of two daily doses of aspirin  widely used to prevent heart attacks and strokes in individuals living with heart disease.  What we learn from the ADAPTABLE study will improve care and outcomes for patients with heart disease and could prevent as many as 88,800 deaths per year around the world.

Adaptable is considered a pragmatic trial. Pragmatic trials are designed to reflect “real-world” medical practice, with the actual work of the study taking place in a variety of clinical settings and amongst a broad patient population. Pragmatic trials use input from health systems and produce results that can be readily used to improve patient care. Pragmatic trials have been benefiting health care for decades. The polio vaccine studies in the 1950s and early aspirin studies for the treatment of acute heart attacks in the 1980s and 1990s are examples of pragmatic research.

Final Protocol and Consent Available

Seeking input at every critical step, from consent design and protocol development, through dissemination of final study results, ADAPTABLE represents a transformative approach to developing a new, efficient, and interactive clinical trial model. Unprecedented in the design of clinical trials, the final consent form and protocol were shaped with input from patients, local institutional review boards, physicians, and study coordinators.

ADAPTABLE is the first demonstration project to be conducted through PCORnet, the National Patient-Centered Clinical Research Network. PCORI is developing PCORnet to enhance the nation’s capacity to conduct much-needed health research studies more quickly and efficiently, less expensively, and with greater potential impact than is now possible.

Funding

The ADAPTABLE study is funded through a Patient-Centered Outcomes Research Institute (PCORI) Award (Contract Number: ASP-1502-27079). ADAPTABLE is the first demonstration project to be conducted through PCORnet, the National Patient-Centered Clinical Research Network. PCORnet is a PCORI-funded initiative designed to improve the nation’s capacity to conduct comparative clinical effectiveness research. More information about PCORnet can be found here.

The information presented on this website does not necessarily represent the views of PCORI, its Board of Governors or Methodology Committee. More information about PCORI can be found here.