ADAPTABLE physician leaders Robert Harrington and Matthew Roe along with operations team leaders Lisa Berdan and Tyrus Rorick presented ADAPTABLE to the American College of Cardiology (ACC) Board of Governors (BOG) on April 1, 2016 during the annual ACC scientific sessions. The ACC BOG is the grassroots liaison organization that represents the local state ACC ...
Another CDRN, Mid-South received full Intuitional Review Board (IRB) approval to conduct the ADAPTABLE study. Before a research study starts enrolling participants, the protocol (study plan) needs to be reviewed by someone not connected to the research to be sure it is ethical, provides potential benefits, and does not cause unnecessary harm to participants. This ...
An article published in Circulation by a group of authors from the Duke Clinical Institute, some of whom are investigators and leaders in ADAPTABLE describes tensions between pragmatic clinical trial design and Good Clinical Practice (GCP) guidelines, which were established in 1996 to help ensure the safety of participants in clinical trials and the validity ...
In this feature of Ask ADAPTABLE, we speak with Dr. Laura Beskow, ADAPTABLE Co-investigator who, along with her team, led the development of the ADAPTABLE consent form.
Q: Why did ADAPTABLE need a new approach to consent form development?
LB: My work has been devoted to studying ethical issues in research and informed consent raises many ...
A conversation with Laura M. Beskow, MPH, PhD, ADAPTABLE Co-Investigator, Duke University
A core aspiration of PCORnet is to redirect the culture of clinical research from researcher-directed to patient-driven. In this spirit, the Duke Clinical Research Institute’s Program for Empirical Bioethics, headed by Dr. Laura Beskow, developed a patient-centered informed consent process for the ADAPTABLE study. ...
Dr. Matthew Roe, co-principal investigator of the ADAPTABLE study, talks about the rationale and process involved in posting the ADAPTABLE draft protocol for public review and comment and how the feedback received impacted the final protocol.
In these videos, Dr. Matthew Roe and Dr. Schuyler Jones explore:
The unique and Innovative Elements of ADAPTABLE
Who is Involved with ADAPTABLE
The Role of Open Science and the Impact of ADAPTABLE
Clinician Engagement in ADAPTABLE
The Importance of ADAPTABLE to Clinicians
Adrian Hernandez, MD, MHS, discusses the important questions to be answered by the ADAPTABLE aspirin dosage study and how it will be conducted faster and more efficiently using the data resources of PCORnet.