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Lessons Learned in ADAPTABLE: Recruitment, Retention, and Endpoint Ascertainment

March 7, 2018 @ 2:00 pm - 3:00 pm

At the March PCORnet Best Practice Sharing Session, Co-Principal Investigator Schuyler Jones and Project Leader Holly Robertson will share early lessons from the design and conduct of The ADAPTABLE Study, the first prospective, large, pragmatic trial conducted within PCORnet. The discussion will focus on recruitment, retention, and endpoint ascertainment.

Schuyler Jones is an interventional cardiologist and his clinical interests include peripheral artery disease, coronary artery disease, and percutaneous coronary intervention. Currently, he serves as  director of the Duke University Cardiac Catheterization Laboratory and the medical director of the Duke Heart Center Clinical Research Unit that oversees site-based research within the Heart Center. Since joining the Duke Faculty in 2010, Dr. Jones has worked as an investigator at the Duke Clinical Research Institute (DCRI) where he has been part of the leadership team for several clinical trials across a broad spectrum of cardiovascular care. He serves as the Co-Medical Director of the Clinical Endpoints Committee at DCRI, and has been an active participant in the angiographic core laboratory at DCRI. He has also been funded by the American Heart Association and the Doris Duke Charitable Foundation to investigate factors associated with the use and outcomes of peripheral vascular intervention.


Holly Robertson is a project leader in the Global Outcomes MegaTrials group at DCRI with over 15 years of experience in pre-clinical and clinical research. Prior to joining DCRI, Robertson obtained her PhD in Pharmacology from the University of Colorado Health Sciences Center in Denver, CO and completed her post-doctoral work at Duke University in the Neurobiology department. She then spent several years managing a large research team in the McGovern Institute for Brain Research at Massachusetts Institute of Technology with appointments at the Broad Institute and the Stanley Center for Psychiatric Research. She currently leads the PCORI-funded ADAPTABLE Study, which is the first study to enroll patients using the PCORnet infrastructure of clinical data, patient-powered, and health plan research networks. She leads a multi-disciplinary team who collaborate across participating partners to design and implement large pragmatic clinical studies, focusing on the use of innovative techniques including e-consent and integration of trial activities within healthcare systems. She is passionate about patient-centered research and the building of collaborative communities of patients, researchers, and clinicians to improve the design and execution of clinical studies to improve quality of care.

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